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The link between perinatal glucocorticoids exposure and psychiatric disorders
1Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. huang_li@pie.com.tw
Pediatric Research
|February 4, 2011
Summary
Perinatal stress can permanently alter stress systems, leading to psychopathology. Glucocorticoid exposure during this sensitive period programs future physiological and behavioral functions, contributing to developmental origins of psychiatric disorders.
Area of Science:
- Neuroscience
- Developmental Psychology
- Endocrinology
Background:
- The perinatal period is a critical window for development, highly susceptible to environmental influences.
- Perinatal adversities can disrupt the programming of stress-regulating systems, impacting long-term health.
- Altered glucocorticoid levels and hypothalamic-pituitary-adrenal (HPA) axis activity are implicated in these programming effects.
Purpose of the Study:
- To review integrated data on the programming effects of perinatal glucocorticoid exposure.
- To discuss the concept of developmental origins of psychiatric disorders.
Main Methods:
- Review of integrated data from human studies.
- Review of integrated data from animal models.
Main Results:
- Perinatal glucocorticoid exposure can lead to permanent alterations in stress-regulating systems.
- These alterations can mediate the programming of physiological, endocrinological, and behavioral functions.
- Evidence from both human and animal studies supports these programming effects.
Conclusions:
- Perinatal adversity, particularly via glucocorticoid exposure, plays a significant role in the developmental origins of psychiatric disorders.
- Understanding these mechanisms is crucial for preventing and treating mental health conditions.
- The programming effects highlight the long-lasting impact of early-life experiences on brain function and behavior.
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