Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision Measurement of Neutrino Oscillation Parameters with 10 Years of Data from the NOvA Experiment.

Physical review letters·2026
Same author

Widespread slow growth of acquisitive tree species.

Nature·2025
Same author

Silicosis initially presenting with empyema.

Occupational medicine (Oxford, England)·2024
Same author

Authors' Response to Correspondence Re Ethnic Differences in Radiotherapy Outcomes in a Majority South Asian Leicester Community.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Predicting CO<sub>2</sub> production of lactating dairy cows from animal, dietary, and production traits using an international dataset.

Journal of dairy science·2024
Same author

Oral Cavity Cancers: Ethnic Differences in Radiotherapy Outcomes in a Majority South Asian Leicester Community.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same journal

Impact of virtual case conferences between primary care clinicians and an interdisciplinary chronic pain clinic.

Canadian family physician Medecin de famille canadien·2026
Same journal

Canadian family physician Medecin de famille canadien·2026
Same journal

Predictors of high-performing family medicine clinics: Prospective cohort study in Alberta.

Canadian family physician Medecin de famille canadien·2026
Same journal

Acetylsalicylic acid use for artial fibrillation and bleeding risk.

Canadian family physician Medecin de famille canadien·2026
Same journal

Clinical practice guidelines: Important tools to teach the art of medicine.

Canadian family physician Medecin de famille canadien·2026
Same journal

Paratonia in advanced dementia: Challenges and evidence-based interventions.

Canadian family physician Medecin de famille canadien·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Diabetes update.

C Reynolds, J Hunt

    Canadian Family Physician Medecin De Famille Canadien
    |February 4, 2011
    PubMed
    Summary
    This summary is machine-generated.

    A new classification system for diabetes mellitus and glucose intolerance, including five clinical and two risk classes, offers greater uniformity. Advances in purification have led to highly pure insulins with minimal contamination.

    More Related Videos

    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
    10:03

    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

    Published on: February 28, 2013

    Related Experiment Videos

    Last Updated: Jun 4, 2026

    Improving IV Insulin Administration in a Community Hospital
    12:08

    Improving IV Insulin Administration in a Community Hospital

    Published on: June 11, 2012

    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
    10:03

    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

    Published on: February 28, 2013

    Area of Science:

    • Endocrinology
    • Metabolic Disorders

    Background:

    • Diabetes mellitus and glucose intolerance classifications have historically lacked uniformity.
    • Advances in insulin purification technology are notable.

    Purpose of the Study:

    • To summarize the new classification of diabetes mellitus and other glucose intolerances.
    • To present clinically important aspects of newly purified insulins.

    Main Methods:

    • Detailed presentation of recommended criteria for clinicians and researchers.
    • Inclusion of information on oral glucose tolerance testing and normal glucose tolerance.
    • Highlighting differences in glucose metabolism across different populations (adults, children, pregnant females).

    Main Results:

    • Introduction of five clinical classes: Type I (insulin-dependent diabetes mellitus, IDDM), Type II (non-insulin-dependent, NIDDM), "other types", gestational diabetes (GDM), and impaired glucose tolerance (IGT).
    • Establishment of two mutually exclusive statistical risk classes: previous abnormality of glucose tolerance (Prev AGT) and potential abnormality of glucose tolerance (Pot AGT).
    • New insulins characterized by high purity due to advanced purification methods, with significantly reduced contamination.

    Conclusions:

    • The new classification provides much-needed uniformity in the field of diabetes and glucose intolerance.
    • Newly purified insulins represent an advancement in purity, not formulation.
    • The classification criteria and insights into glucose metabolism differences are crucial for clinical practice and research.