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Related Experiment Video

Updated: Jun 4, 2026

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency
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Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

Published on: January 15, 2017

Bypass materials in vascular surgery.

Daniela Eidt1, Stephanie Roll, Werner Kulp

  • 1Forschungsstelle für Gesundheitsökonomie und Gesundheitssystemforschung, Universität Hannover, Deutschland.

GMS Health Technology Assessment
|February 4, 2011
PubMed
Summary

Autologous vein grafts are superior for bypass surgery compared to synthetic materials like PTFE or Dacron. Further research is needed on the cost-effectiveness of different bypass materials in vascular surgery.

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Area of Science:

  • Vascular Surgery
  • Health Technology Assessment
  • Health Economics

Background:

  • Arteriosclerosis causes circulatory issues, treated with medication, risk factor management, and surgery.
  • Bypass surgery is crucial for long-segment arterial occlusions, using autologous veins or synthetic grafts (PTFE, Dacron).
  • Analysis of bypass materials is vital for refining Germany's DRG system and understanding cost structures for hospitals and insurers.

Purpose of the Study:

  • Compare bypass materials in vascular surgery based on medical efficiency and cost-effectiveness.
  • Evaluate ethical, social, and legal implications of different bypass materials.
  • Identify research gaps in medical, epidemiological, and health economic aspects of bypass materials.

Main Methods:

  • Structured literature search of multiple databases (DIMDI, Cochrane, MEDLINE, EMBASE, etc.) and manual searches.

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Last Updated: Jun 4, 2026

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency
07:22

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

Published on: January 15, 2017

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
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Published on: August 28, 2014

  • Inclusion of German and English literature published between 1999 and 2004.
  • Methodical quality assessment using standardized checklists, with no limits on the target population.
  • Main Results:

    • Autologous vein grafts demonstrated superiority over human umbilical vein (HUV) and synthetic materials (PTFE, Dacron) in systematic reviews and RCTs.
    • No significant medical differences were found between various synthetic bypass materials.
    • Limited economic data exists; only one study compared costs, and few addressed cost-effectiveness or quality of life.

    Conclusions:

    • Autologous vein is generally preferred for bypass grafts due to medical considerations, though surgeon choice depends on factors like bypass area and patient health.
    • Comparisons of synthetic materials showed no distinct advantages; future synthetic materials require further study.
    • Significant need for further health economic research on bypass materials, including cost-effectiveness and quality of life.