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Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological,
Azadeh Asefnejad1, Aliasghar Behnamghader, Mohammad Taghi Khorasani
1Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. asefnejad_azadeh@yahoo.com
International Journal of Nanomedicine
|February 4, 2011
Summary
New nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds show promise for bone tissue engineering. Higher nFHA content improved mechanical properties while maintaining suitable porosity for tissue regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Materials Science
Background:
- Bone tissue engineering requires advanced scaffolds with specific mechanical and morphological properties.
- Developing composite materials that mimic native bone structure is crucial for successful regeneration.
Purpose of the Study:
- To fabricate and characterize novel nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds.
- To evaluate the influence of nFHA content on the physical and mechanical properties of the scaffolds for bone regeneration applications.
Main Methods:
- Polyester urethane synthesis using polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol.
- Sol-gel synthesis of nano fluor-hydroxyapatite (nFHA).
- Fabrication of porous composite scaffolds via solid-liquid phase separation and solvent sublimation.
- Characterization using compressive testing, Fourier transform infrared spectroscopy, and scanning electron microscopy (SEM).
Main Results:
- SEM confirmed interconnected and homogeneously distributed pores within the scaffolds, ranging from 50-250 μm.
- Increasing nFHA content led to decreased porosity and average pore size.
- Compressive modulus of the scaffolds increased with higher nFHA percentages.
Conclusions:
- The fabricated nFHA/polyurethane composite scaffolds exhibit tunable porosity and enhanced mechanical properties.
- Scaffolds with higher nFHA ratios demonstrate significant potential for bone tissue regeneration due to their favorable characteristics.
