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A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening
Dilek B Silfeler1, Bulent Tandogan, Habibe Ayvaci
1Division of Perinatology, Department of Obstetrics and Gynecology, Mustafa Kemal University Faculty of Medicine, Antakya, Hatay, Turkey. drsilfeler@yahoo.com
Objective:
We compared the safety and effectiveness of oxytocin, dinoprostone and misoprostol for cervical priming.
Study Design:
A total of 218 patients were enrolled to receive between one and three treatments according to physicians' options. The end points were: (1) vaginal delivery or Bishop score ≥ 8 at the end of 12 h, (2) vaginal delivery by 12 h or difference ≥ 4 between the initial and 12th hour Bishop scores. Statistical analyses were performed with ANOVA, Krustal Wallis, Scheffe, χ², Fisher, Advanced χ², and Kolmogorov-Smirnov tests. Tukey's HSD was used as a post hoc test.
Results:
Misoprostol showed statistical significance for the rate of vaginal delivery <12 h, ≥ 8 Bishop score at the end of 12 h, and cervical change of ≥ 4 Bishop scores within 12 h (p = 0.013).
Conclusions:
Comparison between cases Bishop score <4 showed that misoprostol is more effective than dinoprostone and oxytocin. Considering Bishop score = 0 cases we calculated no statistical significance.
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