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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Related Experiment Video

Updated: Jun 4, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

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Angiogenesis in meningiomas.

Valeria Barresi1

  • 1Department of Human Pathology, University of Messina, Messina, Italy. vbarresi@unime.it

Brain Tumor Pathology
|February 4, 2011
PubMed
Summary

Neoangiogenesis, the formation of new blood vessels, is linked to aggressive tumors. Quantifying angiogenesis in meningiomas may predict tumor behavior and guide new anti-angiogenic therapies.

Area of Science:

  • Neuro-oncology
  • Tumor biology
  • Vascular biology

Background:

  • Neoangiogenesis is associated with tumor aggressiveness and poor prognosis in various cancers.
  • The prognostic significance of angiogenesis in meningiomas remains debated.
  • Understanding angiogenesis is crucial for developing targeted therapies for meningiomas.

Purpose of the Study:

  • To review methods for quantifying angiogenesis in meningiomas.
  • To discuss factors regulating angiogenesis in meningiomas.
  • To explore the prognostic implications of angiogenesis in meningiomas.

Main Methods:

  • Review of existing literature on angiogenesis quantification in meningiomas.
  • Analysis of studies utilizing specific markers and scoring systems for angiogenesis.

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  • Examination of research on angiogenesis-regulating factors in meningiomas.

    • Main Results:

    • Quantified angiogenesis correlates with high tumor growth fraction, recurrence, and reduced survival in meningiomas.
    • Despite controversy, robust quantification suggests a significant prognostic role.
    • Angiogenesis may serve as a therapeutic target for inoperable or recurrent meningiomas.

    Conclusions:

    • Accurate quantification of neoangiogenesis is vital for understanding meningioma behavior.
    • Identifying angiogenesis mediators can lead to novel anti-angiogenic treatments.
    • Targeting neoangiogenesis offers potential for improved meningioma management.