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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Resting Membrane Potential01:24

Resting Membrane Potential

The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...

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Related Experiment Video

Updated: Jun 4, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Voltage sensing in thermo-TRP channels.

Sebastian Brauchi1, Patricio Orio

  • 1Facultad de Medicina, Instituto de Fisiologia, Universidad Austral de Chile, Valdivia 511-0566, Chile. sbrauchi@docentes.uach.cl

Advances in Experimental Medicine and Biology
|February 4, 2011
PubMed
Summary
This summary is machine-generated.

Voltage and temperature changes alter the structure of thermo-TRP channels, affecting their pore opening. Understanding this communication between sensor domains and the pore is key to ion channel function.

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Last Updated: Jun 4, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

Controllable Ion Channel Expression through Inducible Transient Transfection
10:00

Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

Area of Science:

  • Biophysics
  • Molecular Biology
  • Ion Channel Physiology

Background:

  • Ion channels are crucial for cellular function, responding to various stimuli.
  • TRP channels, a class of cation-permeable channels, share distant evolutionary links with voltage-gated potassium channels.
  • Gating mechanisms, particularly the communication between stimulus sensors and the pore, remain a significant research area.

Purpose of the Study:

  • To summarize current knowledge on thermo-TRP channel activation.
  • To elucidate the roles of voltage and temperature in thermo-TRP channel gating.
  • To explore the communication pathways between sensor domains and the ion channel pore.

Main Methods:

  • Review of existing biophysical and molecular biology research on TRP channels.
  • Analysis of conformational changes induced by voltage and temperature.
  • Comparative study with voltage-gated potassium channels.

Main Results:

  • Voltage and temperature are key physical stimuli that induce conformational changes in TRP channels.
  • These stimuli modulate the communication between sensor domains and the channel pore, controlling ion flux.
  • Thermo-TRP channels exhibit unique gating properties influenced by both temperature and membrane potential.

Conclusions:

  • Understanding thermo-TRP channel gating requires investigating the interplay between physical stimuli and protein structure.
  • The molecular mechanisms underlying stimulus-sensor to pore communication are critical for ion channel function.
  • Further research into thermo-TRP channels will advance our knowledge of ion channel biophysics and physiology.