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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...

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Related Experiment Video

Updated: Jun 4, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

TRP channels and neural persistent activity.

Antonio Reboreda1, Lydia Jiménez-Díaz, Juan D Navarro-López

  • 1Section of Physiology, Department of Functional Biology and Health Sciences, School of Biology, University of Vigo, Campus Lagoas-Marcosende 36310 Vigo (Pontevedra), Spain. areboreda@uvigo.es

Advances in Experimental Medicine and Biology
|February 4, 2011
PubMed
Summary
This summary is machine-generated.

Persistent activity, a sustained neural firing, is crucial for memory and motor control. This review explores the role of TRP-like channels in generating and maintaining this vital neural function.

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Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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Published on: September 4, 2015

Area of Science:

  • Neuroscience
  • Cellular Physiology

Background:

  • Persistent activity, characterized by sustained neuronal firing, is a fundamental property of the nervous system.
  • This activity is implicated in critical functions such as short-term memory, sensory information processing, and motor control, including maintaining limb position.
  • Similar sustained discharges are observed in pain processing pathways.

Purpose of the Study:

  • To review and discuss the potential role of TRP-like channels in the generation and maintenance of persistent neuronal activity.
  • To elucidate the underlying mechanisms of persistent firing, which remain incompletely understood.

Main Methods:

  • Literature review and synthesis of existing research on persistent activity and TRP channels.
  • Discussion of proposed mechanisms involving non-specific cationic (CAN) currents and TRPC channel activation.

Main Results:

  • Persistent activity is observed across various brain regions, including the prefrontal and entorhinal cortices.
  • Mechanisms for persistent firing are hypothesized to involve non-specific cationic currents mediated by TRPC channels.

Conclusions:

  • Persistent neuronal activity is essential for both cognitive and behavioral processes.
  • TRP-like channels are proposed as key players in the generation and maintenance of persistent activity, warranting further investigation.