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Related Concept Videos

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...

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Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
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Published on: July 14, 2018

TRP channels in vascular endothelial cells.

Ching-On Wong1, Xiaoqiang Yao

  • 1Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. chingon.wong@gmail.com

Advances in Experimental Medicine and Biology
|February 4, 2011
PubMed
Summary

Transient Receptor Potential (TRP) channels are key regulators of endothelial cell function, influencing vascular tone, permeability, and angiogenesis. This review highlights recent advances in understanding TRP channel roles in vascular physiology and disease.

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Last Updated: Jun 4, 2026

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Area of Science:

  • Vascular Biology
  • Cell Physiology
  • Ion Channel Research

Background:

  • Endothelial cells control vascular functions like tone, permeability, remodeling, and angiogenesis.
  • Cytosolic Ca(2+) levels and membrane potential are critical for endothelial signal transduction.
  • Transient Receptor Potential (TRP) channels are vital for endothelial ion homeostasis and vascular signaling.

Purpose of the Study:

  • To summarize recent findings on TRP channel research in endothelial cells.
  • To provide updated information for researchers in the field of vascular TRP channels.
  • To elucidate the diverse roles of TRP channels in vascular physiology and pathophysiology.

Main Methods:

  • Review of recent scientific literature on TRP channels in endothelial cells.
  • Analysis of studies investigating TRP channel function in vascular signaling.
  • Synthesis of data on TRP channel involvement in physiological and pathophysiological processes.

Main Results:

  • TRP channels are prime mediators of diverse vascular signaling pathways.
  • TRP channel characteristics (heteromultimerization, ion selectivity, activation modes) enable versatile roles.
  • Numerous TRP channels are implicated in both normal and abnormal vascular system functions.

Conclusions:

  • TRP channels are essential regulators of endothelial cell function and vascular homeostasis.
  • Understanding TRP channel mechanisms offers insights into vascular diseases.
  • Continued research on endothelial TRP channels is crucial for advancing vascular medicine.