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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Updated: Jun 4, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Oncogenic TRP channels.

V'yacheslav Lehen'kyi1, Natalia Prevarskaya

  • 1Department of Molecular Medicine, sapienza University of Rome, 10161 Rome, Italy. vyacheslav.lehenkyi@univ-lille1.fn

Advances in Experimental Medicine and Biology
|February 4, 2011
PubMed
Summary

Transient Receptor Potential (TRP) channels are vital for cell function and are implicated in cancer. Altered TRP channel expression, particularly TRPM8, TRPV6, and TRPM1, is linked to cancer development and progression.

Area of Science:

  • Physiology
  • Molecular Biology
  • Oncology

Background:

  • Transient Receptor Potential (TRP) channels regulate diverse physiological processes.
  • Dysregulation of TRP channel expression is increasingly recognized in various cancers.
  • Specific TRP channels, including TRPM8, TRPV6, and TRPM1, show significant roles in cancer pathogenesis.

Purpose of the Study:

  • To review the role of TRP channels in cancer initiation and progression.
  • To highlight specific TRP channels implicated in cancer development.
  • To explore the potential of TRP proteins as cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review of studies investigating TRP channels in cancer.
  • Analysis of altered expression patterns of TRP channels in different cancer types.

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Controllable Ion Channel Expression through Inducible Transient Transfection
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Controllable Ion Channel Expression through Inducible Transient Transfection

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Last Updated: Jun 4, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Controllable Ion Channel Expression through Inducible Transient Transfection
10:00

Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

  • Examination of the functional roles of specific TRP channels in cancer pathogenesis.

    • Main Results:

    • Altered expression of TRP channels is a common feature in cancer.
    • TRPM8, TRPV6, and TRPM1 are prominently associated with cancer pathogenesis.
    • Other TRP channels like TRPV1, TRPC1, TRPC6, TRPM4, and TRPM5 also show altered expression in certain cancers.

    Conclusions:

    • TRP channels are significantly involved in cancer development and progression.
    • Further research is needed to elucidate the precise roles of TRP channels in oncology.
    • TRP proteins represent promising targets for novel cancer diagnostics and therapeutics.