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Updated: Jun 4, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis, antimicrobial and anticancer activity of new thiosemicarbazone derivatives
Umasankar Kulandaivelu1, Valisakka Gari Padmini, Kyatham Suneetha
1Medicinal Chemistry Research Division, Vaagdevi College of Pharmacy, Hanamkonda, Andhra Pradesh, India. youmasankar@rediffmail.com.
Abstract:
Thiosemicarbazones of p-aminobenzoic acid (PABA) were synthesized and tested for their antimicrobial and anticancer activity. Hydroxamate derivatives 4a-4l were found to have better antimicrobial and anticancer activity than their acid counterpart. Compound 4d was found to have good antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Vibrio cholerae, and Bacillus subtilis with IC(50) value of about 1 µM. Compound 4f showed potent antifungal activity against Candida albicans (IC(50) = 1.29 µM) and compound 4h showed potent anticancer activity (IC(50) = 0.07 µM).
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