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A pH-sensitive chitosan-tripolyphosphate hydrogel beads for controlled glipizide delivery
Summary
Chitosan(CS)-tripolyphosphate (TPP) hydrogel beads were developed for glipizide delivery. These pH-sensitive beads show controlled release, with higher drug release at lower pH levels.
Area of Science:
- Materials Science
- Polymer Chemistry
- Pharmaceutical Sciences
Background:
- Controlled drug delivery systems are crucial for improving therapeutic efficacy.
- Chitosan and tripolyphosphate hydrogels offer biocompatibility and tunable properties.
- Glipizide, an antidiabetic drug, requires effective delivery strategies.
Purpose of the Study:
- To prepare and characterize chitosan(CS)-tripolyphosphate (TPP) hydrogel beads for glipizide delivery.
- To investigate the influence of various factors on hydrogel swelling behavior.
- To evaluate the pH-sensitive drug release profile of the developed hydrogel beads.
Main Methods:
- Ionic gelation method for hydrogel bead preparation.
- FT-IR and SEM for structural and morphological characterization.
- Swelling studies and in vitro drug release experiments at different pH values.
Main Results:
- Hydrogel bead structure and morphology were confirmed.
- Swelling ratio increased with decreasing pH, showing higher swelling at pH 1.5.
- Approximately 90% glipizide release at pH 1.5, compared to 36% at pH 6.8.
Conclusions:
- CS-TPP hydrogel beads demonstrate pH-sensitive swelling and drug release properties.
- The developed hydrogel beads are suitable for controlled glipizide delivery.
- This system offers a promising approach for pH-triggered pharmaceutical applications.
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