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Osteoradionecrosis, pathogenesis, treatment and prevention.
A Westermark1, S Sindet-Pedersen, J Jensen
1Dept. of Oral and Maxillofacial Surgery, Arhus University Hospital, Denmark.
Tandlaegebladet
|November 1, 1990
Summary
Osteoradionecrosis (ORN) of the jaws results from radiation-induced vascular damage, leading to impaired healing. Hyperbaric oxygen therapy (HBO) can improve tissue viability and reduce ORN risk.
Area of Science:
- Oral and Maxillofacial Surgery
- Radiation Oncology
- Vascular Biology
Background:
- Osteoradionecrosis (ORN) is a severe complication following radiation therapy to the head and neck.
- Radiation damages endothelial cells, causing hypoxic, hypovascular, and hypocellular jaw tissues.
- Impaired wound healing in ORN is due to compromised vascular supply.