Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Management of specific medical emergencies in dental practice.

British dental journal·2023

Same author

Cystoscopic findings in women with minimal and maximal lower urinary tract symptoms.

Translational andrology and urology·2021

Same author

Use of Pre-Injection Diffusion of Local Anaesthetic as a Means of Reducing Needle Penetration Discomfort.

Acta stomatologica Croatica·2016

Same author

Determination of the mental foramen position in dental radiographs in 18-30 year olds.

Dento maxillo facial radiology·2015

Same author

Haemostasis. Part 2: Medications that affect haemostasis.

Dental update·2014

Same author

Haemostasis. Part 1: The management of post-extraction haemorrhage.

Dental update·2014

Same journal

Technique Tips – Iatrogenesis and How to Prevent It.

Dental update·2017

Same journal

Clinical Challenges Q&A 31. Painful Lip.

Dental update·2017

Same journal

Dual Role of Subepithelial Connective Tissue Grafting in Regeneration of Periodontal Attachment Apparatus.

Dental update·2017

Same journal

Ceramic Fracture in Metal-Ceramic Restorations: The Aetiology.

Dental update·2017

Same journal

Arteriovenous Malformation of the Jaws: a Black Hole for the GDP – A Case Report.

Dental update·2017

Same journal

The Immune System: Basis of so much Health and Disease: 4. Immunocytes.

Dental update·2017

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Pharmacology and the elderly.

Andrew C Steele¹, John G Meechan

¹Newcastle Dental Hospital, Newcastle Hospitals NHS Foundation Trust, UK.

|February 5, 2011

Summary

This summary is machine-generated.

Ageing affects how individuals process drugs, increasing risks for older dental patients. Understanding drug interactions is crucial for safe dental prescribing in the elderly population.

More Related Videos

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Related Experiment Videos

Last Updated: Jun 4, 2026

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Area of Science:

Gerontology
Pharmacology
Dental Medicine

Background:

Ageing significantly alters drug metabolism and pharmacokinetics.
The elderly population often presents with multiple comorbidities and polypharmacy.
Adverse drug reactions (ADRs) are a major concern in geriatric care.

Purpose of the Study:

To examine the impact of ageing on drug processing.
To review adverse drug reactions in the elderly.
To provide guidance on prescribing for older dental patients.

Main Methods:

Literature review focusing on ageing, drug metabolism, and dental pharmacology.
Analysis of studies on adverse drug reactions in geriatric populations.
Synthesis of clinical guidelines for prescribing in older adults.

Main Results:

Age-related physiological changes can modify drug efficacy and toxicity.
Elderly patients are at higher risk for experiencing adverse drug reactions.
Concurrent medical conditions and medications complicate dental drug prescriptions.

Conclusions:

Older dental patients frequently have existing medical conditions and are on various medications.
These factors significantly influence the effects of drugs prescribed by dentists.
Careful consideration of patient's overall health status and medication regimen is essential for safe and effective dental treatment.