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Photopatterning of cell-adhesive-modified poly(ethyleneimine) for guided neuronal growth
Nam Seob Baek1, Ji-Hyun Lee, Yong Hee Kim
1IT Convergence Technology Research Laboratory, Electronics and Telecommunications Research Institute , 138 Gajeongno, Yuseong-gu, Daejeon 305-700, Republic of Korea.
Abstract:
We describe photopatterning technique that employs the photodegradation of cell-adhesive-modified poly(ethyleneimine) (m-PEI) to fabricate precise micropatterns on the indium tin oxide (ITO) substrate for guided neuronal growth. The photodegradation of m-PEI coated on hydroxyl group-terminated ITO substrate created micropatterns over a large area through deep UV irradiation. The photopatterned m-PEI layer can effectively guide neurite outgrowth and control neurite extensions from individual neurons.
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