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Related Experiment Video

Updated: Jun 4, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

[Thrombinoscopy: measuring thrombin generation].

H Coen Hemker1

  • 1Synapse BV, Cardiovasculair Research Instituut Maastricht (CARIM), The Netherlands. hc.hemker@thrombin.com

Nederlands Tijdschrift Voor Geneeskunde
|February 5, 2011
PubMed
Summary
This summary is machine-generated.

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See all related articles

A new test measuring thrombin generation in blood offers a better assessment of bleeding or clotting risks. This simple test can also monitor antithrombotic drug effectiveness.

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Diagnostics

Context:

  • Assessing hemorrhagic or thrombotic tendencies requires a reliable diagnostic test.
  • Existing clotting time tests have limitations in predicting bleeding or clotting risks.
  • Thrombin generation is emerging as a key indicator in hemostasis.

Purpose:

  • To introduce a novel test for evaluating hemorrhagic and thrombotic tendencies.
  • To demonstrate the superiority of thrombin generation measurement over traditional clotting time assays.
  • To establish thrombin generation as a universal method for assessing antithrombotic drug efficacy.

Summary:

  • A new, simple method allows for the measurement of thrombin concentration in clotting blood or plasma.
  • This thrombin generation test provides a more accurate assessment of bleeding or clotting risk compared to clotting time.

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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Related Experiment Videos

Last Updated: Jun 4, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
08:50

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

  • The test is suitable for routine clinical use and serves as a universal indicator for antithrombotic drug effects.

    • Impact:

    • Provides a more accurate diagnostic tool for hemorrhagic and thrombotic disorders.
    • Enables personalized monitoring of antithrombotic therapy.
    • Facilitates improved patient management and treatment strategies in thrombosis and bleeding conditions.