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[Thrombinoscopy: measuring thrombin generation]

H Coen Hemker1

  • 1Synapse BV, Cardiovasculair Research Instituut Maastricht (CARIM), The Netherlands. hc.hemker@thrombin.com

Nederlands Tijdschrift Voor Geneeskunde
|February 5, 2011
PubMed

A test is needed of which the score is low in case of haemorrhagic tendency and high in case of thrombotic tendency. Emerging evidence shows that thrombin generation is a promising candidate. Recently it became possible to measure the course in thrombin concentration in clotting blood or blood plasma in an simple way suitable for application in a routine clinical setting. It appears that the amount of thrombin developing in clotting blood or blood plasma is a better measure for thrombotic- or haemorrhagic tendency than any variant of the clotting time and that thrombin generation is a universal test for the effect of antithrombotic drugs.

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