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Updated: Jun 4, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Bullous scabies simulating pemphigoid.

T Roxana Stan¹, Stefano Piaserico, Matteo Bordignon

¹Dermatology and Pathology Units, University of Padua, Padua, Italy.

Journal of Cutaneous Medicine and Surgery

|February 5, 2011

Summary

Bullous scabies can mimic autoimmune blistering diseases like bullous pemphigoid. Early diagnosis and treatment with benzyl benzoate are crucial for managing this contagious skin infestation.

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Area of Science:

Dermatology
Parasitology

Background:

Scabies is a common, contagious skin infestation affecting all demographics.
Itching and papules are typical symptoms, but atypical presentations can occur.

Observation:

A 79-year-old male presented with a bullous eruption mimicking autoimmune blistering disease.
Initial investigations, including immunofluorescence and autoantibody testing, were negative.
Skin biopsy unexpectedly revealed scabies mites.

Findings:

Histological examination confirmed scabies infestation as the cause of the bullous eruption.
The patient responded well to treatment with 20% benzyl benzoate.
This case highlights a rare presentation of scabies.

Implications:

Bullous scabies should be considered in the differential diagnosis of bullous eruptions, especially when steroid-resistant and immunopathologically negative.
Accurate diagnosis requires a high index of suspicion and potentially skin biopsy.
Prompt identification and treatment are essential to prevent complications and transmission.