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Updated: Jun 4, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Increasing lipid adherence to goal
Elliot Davidson1, Elizabeth Uhlenhake, Gary McCord
1Akron General Center for Family Medicine, Akron General Medical Center, 400 Wabash Avenue, Akron, OH 44307, USA.
Insights
Utilizing a Mobile Lipid Clinic Personal Digital Assistant (PDA) Calculator effectively helps patients achieve their low-density lipoprotein (LDL) goals, comparable to electronic health records and superior to conventional methods.
Area of Science:
- Cardiology
- Health Informatics
- Preventive Medicine
Background:
- Updated 2004 National Cholesterol Education Program guidelines recommended lower low-density lipoprotein (LDL) levels for high-risk patients.
- Assessing patient risk factors is crucial for setting appropriate LDL goals and guiding therapy.
Purpose of the Study:
- To evaluate if a Personal Digital Assistant (PDA) calculator improves patient achievement of LDL goals compared to electronic medical records (EMRs) or usual care.
- To determine the efficacy of technology-assisted interventions in lipid management.
Main Methods:
- Four family medicine residency programs compared four methods: PDA calculator, EMRs, usual care, and a transition to EMRs.
- 100 patients per site (aged 40-75) with LDL levels 10% above goal were enrolled.
- Follow-up chart reviews assessed LDL reduction and goal achievement.
Main Results:
- The PDA site achieved 27% LDL goal attainment, while the EMR site achieved 19%.
- The transition site reached 32% and the control site 4%.
- Cholesterol-lowering medication use increased significantly from 38% to 47%.
Conclusions:
- Personal Digital Assistant (PDA) tools are as effective as EMRs for achieving patient LDL goals.
- Technology-based interventions demonstrate a benefit over some conventional methods in improving patient outcomes.
- Utilizing technology can enhance patient care and health outcomes in lipid management.
Background:
In April 2004, the National Cholesterol Education Program Adult Treatment Panel III Guidelines for management of high cholesterol encouraged even lower levels of low-density lipoprotein (LDL) than previous guidelines for high and very high risk groups. Assessing patients' risk factors to determine LDL goals is the first step to help guide therapy.
Objective:
To determine whether the use of the Mobile Lipid Clinic Personal Digital Assistant (PDA) Calculator during office visits will increase the number of patients achieving their LDL goal compared to using electronic medical records or conventional methods.
Methods:
Four family medicine residency programs affiliated with the Northeastern Ohio Network participated with each site using a different method. The PDA site used the Mobile Lipid Clinic Calculator, the second site used electronic health records (EHRs), the control site used usual care methods, and the transition site moved from paper charts to EHRs during the study. In 2006, baseline chart reviews were conducted to randomly enroll 100 patients per site (aged 40-75 years) with LDL levels at least 10% above goal. In 2007, follow-up chart reviews were conducted on the same patients to determine reductions in LDL and the percent of patients that reached their LDL goals.
Results:
The percentage reaching their LDL goal and option goal were as follows: PDA site 27% and 12%, EHR site 19% and 3%, control site 4% and 1%, transition site 32% and 12%. Cholesterol-lowering medication usage increased significantly from 38% at baseline to 47% at follow-up (χ(2) = 149.5, P <0.0001).
Conclusions:
Using a PDA tool can be just as effective as EHRs in getting patients to their LDL goal and is better than some conventional methods, suggesting the benefit of utilizing technology to improve patient care and health outcomes.
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