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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Circulating osteocalcin is increased in early-stage diabetes.

Atsushi Aoki1, Takatoshi Muneyuki, Masashi Yoshida

  • 1First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, 1-847 Amanuma, Omiya, Saitama 330-8503, Japan.

Diabetes Research and Clinical Practice
|February 5, 2011
PubMed
Summary

Circulating osteocalcin levels are elevated in type 2 diabetes and correlate with glucose intolerance. Osteocalcin and leptin are independently associated with impaired glucose metabolism, suggesting a link between bone and glucose health.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Bone Metabolism

Background:

  • Bone metabolism and glucose metabolism are reportedly interconnected in human and animal studies.
  • Osteocalcin, a bone formation marker secreted by osteoblasts, is a potential indicator of these metabolic links.

Purpose of the Study:

  • To investigate if circulating osteocalcin levels differ in individuals with glucose intolerance.
  • To explore the relationship between osteocalcin, leptin, and glucose metabolism markers.

Main Methods:

  • Utilized a 75 g oral glucose tolerance test (75 g-OGTT) to categorize subjects into normal glucose tolerance (NGT), prediabetes (PDM), and type 2 diabetes (T2DM).
  • Analyzed serum osteocalcin and leptin levels using regression and multinomial logistic analyses.
  • Correlated osteocalcin with plasma glucose at 120 min (G(120)), creatinine, and C-reactive protein (CRP).

Main Results:

  • Serum osteocalcin levels were significantly increased in the T2DM group compared to the NGT group.
  • Osteocalcin showed a positive correlation with G(120) and negative correlations with creatinine and Ln(CRP).
  • Osteocalcin and leptin were identified as independent predictors of G(120). Leptin was associated with prediabetes, while osteocalcin was independently associated with T2DM compared to NGT.

Conclusions:

  • Circulating osteocalcin and leptin levels are associated with glucose intolerance.
  • These findings suggest a role for osteocalcin and leptin in the complex interplay between bone and glucose metabolism.