A strong case for personalized, targeted cancer prevention
1Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. mdawson@sanfordburnham.org
Cancer Prevention Research (Philadelphia, Pa.)
|February 5, 2011
Summary
Genetic variations predict head and neck cancer recurrence. Specific genotypes in the retinoid X receptor alpha gene significantly reduced risk in patients receiving 13-cis-retinoic acid (13-cRA), advancing personalized cancer prevention.
Area of Science:
- Oncology
- Genetics
- Cancer Prevention
Background:
- A previous phase III trial evaluated low-dose 13-cis-retinoic acid (13-cRA) for preventing second primary tumors (SPT) or recurrence in head and neck cancer patients.
- Understanding genetic factors influencing treatment response is crucial for personalized medicine.
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