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Comparative studies on Clostridium botulinum type A strains associated with infant botulism in Japan and in
K Tabita1, S Sakaguchi, S Kozaki
1Osaka Prefectural Institute of Public Health.
Japanese Journal of Medical Science & Biology
|December 1, 1990
Abstract:
Twenty strains of Clostridium botulinum type A associated with infant botulism cases, six in Japan and 14 in California, USA, were compared in their characters. All six Japanese strains produced medium-sized progenitor toxin (M toxin; Mr 300 k) but no hemagglutinin and showed lower 50% infective doses (ID50) in the infant mouse test; whereas most American strains produced large-sized progenitor toxin (L + LL toxins; Mr 500 k and 900 k) and hemagglutinin in addition to M toxin and showed higher ID50 in infant mice. No marked difference in the biochemical properties was found between the two groups except for two American strains.