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The effect of syncope on brain natriuretic peptide
Matthew J Reed1, Louise Gibson
1Emergency Medicine Research Group, Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK. matthew.reed@luht.scot.nhs.uk
Brain natriuretic peptide (BNP) levels increase after syncope, peaking between 18 hours and 1 week. This study tracked BNP changes in older adults following emergency department visits for syncope.
Area of Science:
- Cardiology
- Emergency Medicine
- Biomarkers
Background:
- Brain natriuretic peptide (BNP) is a potential prognostic marker for syncope.
- Investigating BNP changes following acute syncope presentations is crucial.
Purpose of the Study:
- To determine if Brain natriuretic peptide (BNP) levels change following an acute syncope event.
- To establish the temporal pattern of BNP changes in patients presenting with syncope.
Main Methods:
- Prospective enrollment of patients aged 60 years and older admitted with syncope.
- Serial Brain natriuretic peptide (BNP) measurements taken on admission and up to 4 weeks post-presentation.
Main Results:
- Mean Brain natriuretic peptide (BNP) increased from baseline (167.8 ng/ml) to a peak of 303.2 ng/ml at 48 hours.
- The Brain natriuretic peptide (BNP) ratio peaked at 2.4 at 1 week, returning to baseline by 4 weeks.
Conclusions:
- Brain natriuretic peptide (BNP) levels appear to rise post-syncope, peaking between 18 hours and 1 week.
- The underlying mechanisms driving this Brain natriuretic peptide (BNP) elevation remain unclear.
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