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[Regulation of prolactin secretion at the cellular level].

M Bilinski¹, J H Tramezzani

¹Instituto de Neurobiología, Buenos Aires, Argentina.

Acta Physiologica Et Pharmacologica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y De La Asociacion Latinoamericana De Farmacologia

|January 1, 1990

Summary

This review examines mechanisms regulating mammalian prolactin (PRL) secretion. While dopamine

Area of Science:

Neuroendocrinology
Cell Biology
Biochemistry

Background:

Prolactin (PRL) secretion is crucial for mammalian reproduction and development.
Understanding the regulation of PRL secretion is complex due to numerous interacting factors.

Purpose of the Study:

To review two decades of research on the mechanisms regulating mammalian prolactin (PRL) secretion.
To identify gaps in knowledge and suggest future research directions.

Main Methods:

Compilation and discussion of existing research on PRL secretion.
Analysis of methodological aspects, cellular signaling pathways, and neuroendocrine modulators.
Review of PRL secretory granule morphology and biochemistry.

Main Results:

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Dopaminergic inhibition of PRL release is well-established.
Significant progress has been made in understanding second messenger actions and thyrotropin-releasing hormone.
The field of "new neuroendocrinology" involving peptides requires further investigation.

Conclusions:

Current understanding of PRL secretion regulation remains incomplete.
Further research using advanced cytochemical techniques and specific pharmacological agents is needed.
Elucidating the role of peptides and subpopulations of PRL-secreting cells is essential for future advancements.