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[Regulation of prolactin secretion at the cellular level]
1Instituto de Neurobiología, Buenos Aires, Argentina.
Acta Physiologica Et Pharmacologica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y De La Asociacion Latinoamericana De Farmacologia
|January 1, 1990
Summary
This review examines mechanisms regulating mammalian prolactin (PRL) secretion. While dopamine
Area of Science:
- Neuroendocrinology
- Cell Biology
- Biochemistry
Background:
- Prolactin (PRL) secretion is crucial for mammalian reproduction and development.
- Understanding the regulation of PRL secretion is complex due to numerous interacting factors.
Purpose of the Study:
- To review two decades of research on the mechanisms regulating mammalian prolactin (PRL) secretion.
- To identify gaps in knowledge and suggest future research directions.
Main Methods:
- Compilation and discussion of existing research on PRL secretion.
- Analysis of methodological aspects, cellular signaling pathways, and neuroendocrine modulators.
- Review of PRL secretory granule morphology and biochemistry.
Main Results:
- Dopaminergic inhibition of PRL release is well-established.
- Significant progress has been made in understanding second messenger actions and thyrotropin-releasing hormone.
- The field of "new neuroendocrinology" involving peptides requires further investigation.
Conclusions:
- Current understanding of PRL secretion regulation remains incomplete.
- Further research using advanced cytochemical techniques and specific pharmacological agents is needed.
- Elucidating the role of peptides and subpopulations of PRL-secreting cells is essential for future advancements.
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