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Updated: Jun 4, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Fluid resuscitation in multiple trauma patients.

Christian Ertmer1, Tim Kampmeier, Sebastian Rehberg

  • 1Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany.

Current Opinion in Anaesthesiology
|February 5, 2011
PubMed
Summary

Fluid resuscitation in trauma patients with hemorrhagic shock requires careful consideration. Hypertonic solutions may be beneficial, especially with co-existing brain injury, while avoiding crystalloids is suggested.

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Area of Science:

  • Trauma Management
  • Resuscitation Strategies
  • Hemorrhagic Shock

Background:

  • Fluid resuscitation in trauma with hemorrhagic shock is debated.
  • Co-existing brain injury complicates management.
  • Current knowledge on nonblood fluid resuscitation is summarized.

Purpose of the Study:

  • To review current knowledge on nonblood fluid resuscitation in trauma patients with hemorrhagic shock.
  • To discuss fluid choices in multiple trauma patients.
  • To evaluate the role of fluids in patients with traumatic brain injury.

Main Methods:

  • Literature review of current evidence.
  • Analysis of experimental and clinical data.
  • Summary of findings on fluid therapy efficacy and risks.

Main Results:

  • Aggressive fluid challenges may be detrimental in uncontrolled hemorrhage.
  • Isotonic crystalloids can lead to hypothermia, acidosis, and inflammation.
  • Hypertonic solutions may benefit traumatic brain injury patients by reducing inflammation and intracranial pressure.

Conclusions:

  • No large-scale studies confirm or refute nonblood fluid resuscitation for hemorrhagic shock in trauma.
  • Hypertonic solutions are preferred over crystalloids; the role of colloids is undefined.
  • Avoid hypotension and hypotonic solutions in brain-injured patients; hypertonic solutions offer benefits beyond hemodynamics.