Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Pneumothorax-I01:26

Pneumothorax-I

A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infective endocarditis: prevention, diagnosis and treatment.

Canadian family physician Medecin de famille canadien·2011
Same author

Respiratory tract infections in adults.

Canadian family physician Medecin de famille canadien·2011
Same author

Drug treatment of cardiac failure.

Canadian family physician Medecin de famille canadien·2011
Same author

The use of antimicrobial drugs in office practice.

Canadian family physician Medecin de famille canadien·2010
Same author

Rational and irrational use of antibiotics.

Canadian Medical Association journal·2010
Same author

Emergency drugs.

Canadian Medical Association journal·2010
Same journal

Impact of virtual case conferences between primary care clinicians and an interdisciplinary chronic pain clinic.

Canadian family physician Medecin de famille canadien·2026
Same journal

Canadian family physician Medecin de famille canadien·2026
Same journal

Predictors of high-performing family medicine clinics: Prospective cohort study in Alberta.

Canadian family physician Medecin de famille canadien·2026
Same journal

Acetylsalicylic acid use for artial fibrillation and bleeding risk.

Canadian family physician Medecin de famille canadien·2026
Same journal

Clinical practice guidelines: Important tools to teach the art of medicine.

Canadian family physician Medecin de famille canadien·2026
Same journal

Paratonia in advanced dementia: Challenges and evidence-based interventions.

Canadian family physician Medecin de famille canadien·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

Septic shock.

M R Achong

    Canadian Family Physician Medecin De Famille Canadien
    |February 5, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Septic shock, a severe condition of inadequate tissue perfusion, often stems from Gram-negative rod bacteremia. Early recognition is crucial, as initial symptoms can be subtle, especially in elderly patients.

    More Related Videos

    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
    05:56

    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

    Published on: February 20, 2021

    Related Experiment Videos

    Last Updated: Jun 4, 2026

    Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
    05:52

    Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

    Published on: December 8, 2023

    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
    05:56

    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

    Published on: February 20, 2021

    Area of Science:

    • Critical Care Medicine
    • Infectious Diseases
    • Pathophysiology

    Background:

    • Septic shock is a life-threatening condition characterized by inadequate tissue perfusion.
    • Microbial invasion of the bloodstream, particularly Gram-negative rod bacteremia, is a common cause.
    • The syndrome's classic signs include fever, hypotension, and oliguria, but early manifestations can be non-specific.

    Purpose of the Study:

    • To describe the clinical features and management principles of septic shock.
    • To highlight the challenges in early diagnosis, especially in vulnerable populations like the elderly.
    • To outline the multifaceted treatment approach for septic shock.

    Main Methods:

    • Review of clinical presentations of septic shock.
    • Analysis of causative agents, focusing on Gram-negative bacteremia.
    • Discussion of diagnostic criteria and therapeutic strategies.

    Main Results:

    • Gram-negative rod bacteremia is identified in approximately two-thirds of septic shock cases.
    • The fully developed syndrome is recognizable, but initial symptoms can be subtle and easily missed.
    • Elderly patients present particular diagnostic challenges due to non-specific initial signs.

    Conclusions:

    • Effective management of septic shock requires prompt identification and elimination of the underlying infection.
    • Improving tissue perfusion and supporting vital functions are critical therapeutic goals.
    • Comprehensive management includes addressing specific complications alongside primary treatment.