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Seasonal variation of hypertrophic pyloric stenosis: a population-based study

Mohammed F Zamakhshary1, Sanjeev Dutta, Teresa To

  • 1Division of Pediatric Surgery, King Fahad Hospital, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia. zamakhshary@gmail.com

Pediatric Surgery International
|February 5, 2011
PubMed

Insights

Seasonal variation in hypertrophic pyloric stenosis (HPS) is significant, with higher incidence rates observed during summer months. This finding suggests environmental factors may play a role in the development of HPS.

Area of Science:

  • Pediatric Surgery
  • Epidemiology
  • Infant Health

Background:

  • The incidence of hypertrophic pyloric stenosis (HPS) and its potential seasonal variation has been a subject of ongoing debate.
  • Understanding seasonal patterns in HPS can provide insights into potential etiological factors.

Purpose of the Study:

  • To investigate and confirm the existence of seasonal variation in the incidence of hypertrophic pyloric stenosis.
  • To analyze HPS incidence across different seasons to identify peak occurrence periods.

Main Methods:

  • A population-based cohort study analyzed 1,777 infants diagnosed with HPS in Ontario, Canada, between 1993 and 2000.
  • Incidence rates were adjusted for birth rates and expressed per 100,000 infants under 12 months.
  • Statistical analyses, including one-way ANOVA, time series, and spectral analysis, were employed to assess seasonal trends.

Main Results:

  • The study identified a statistically significant seasonal variation in HPS incidence.
  • The highest incidence of HPS and pyloromyotomy occurred in the summer, particularly in June.
  • Conversely, the lowest rates were observed in winter, with February showing the lowest incidence (p = 0.0014).

Conclusions:

  • Hypertrophic pyloric stenosis incidence is higher during the summer months.
  • The observed seasonal variation supports the hypothesis that environmental factors may contribute to the etiology of HPS.
  • Further research into specific environmental triggers is warranted.
Abstract

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