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Fos and jun: two into one will go

J R Woodgett1

  • 1Ludwig Institute for Cancer Research, London, UK.

Seminars in Cancer Biology
|December 1, 1990
PubMed

Insights

The discovery of c-jun as a transcription factor revealed gene regulation

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • The identification of c-jun as the first oncogene transcription factor.
  • The prediction that gene regulation is crucial for growth control.

Purpose of the Study:

  • To describe the progress in understanding c-jun and c-fos.
  • To elucidate their normal cellular functions.

Main Methods:

  • Review of initial characterization studies.
  • Analysis of current understanding of oncogene function.

Main Results:

  • c-jun functions with c-fos as a transcription factor.
  • This complex transduces hormonal signals.
  • Both are archetypal members of gene families.

Conclusions:

  • Significant progress has been made in understanding these oncogenes.
  • Their normal cellular roles are now better understood.

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