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Invasive pneumococcal disease in Phramongkutklao Hospital 2004-2008: clinical data, serotype distribution and

Detchvijitr Suwanpakdee1, Rudiwilai Samakoses, Sayomporn Sirinavin

  • 1Pediatric Infectious Disease Unit, Phramongkutklao Hospital, Bangkok, Thailand. detchvijitr@gmail.com

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|February 8, 2011
PubMed
Abstract

Insights

Invasive pneumococcal disease (IPD) disproportionately affected young children and the elderly in Bangkok. Penicillin resistance in meningitis cases highlights the need for better treatment and vaccines.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Invasive pneumococcal disease (IPD) remains a significant global health concern.
  • Understanding local epidemiology, including serotype distribution and antimicrobial resistance, is crucial for effective management.

Purpose of the Study:

  • To characterize the clinical presentation, serotype prevalence, and antibiotic resistance of IPD cases.
  • To inform local public health strategies and clinical treatment guidelines.

Main Methods:

  • Retrospective analysis of IPD cases from January 2004 to December 2008.
  • Serotyping and antibiotic susceptibility testing performed on available isolates.

Main Results:

  • Fifty-one IPD cases identified; 47 with available records.
  • Peak incidence in children under 5 and adults over 60.
  • Meningitis cases showed high penicillin resistance (4/7 isolates) and reduced cefotaxime susceptibility (1/7).
  • Overall case fatality rate was 19%.

Conclusions:

  • IPD predominantly impacts the very young and elderly in Bangkok.
  • High penicillin resistance in pneumococcal meningitis necessitates optimized treatment and vaccination strategies.

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