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Early transcriptional events in cell growth: the Egr family

V P Sukhatme1

  • 1Department of Medicine (Nephrology), University of Chicago, Pritzker School of Medicine, 60637.

Journal of the American Society of Nephrology : JASN
|December 1, 1990
PubMed

Insights

Eukaryotic cells utilize early growth response genes, encoding transcription factors, to mediate responses to diverse extracellular signals beyond just cell growth. Understanding these zinc finger factors offers insights into cellular signal transduction pathways.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Eukaryotic cell response to growth signals is critical.
  • Focus is shifting from second messenger pathways to transcriptional events.
  • Mitogens induce genes without new protein synthesis, including immediate-early genes.

Purpose of the Study:

  • To review the early growth response (EGR) group of zinc finger transcription factors.
  • To elucidate the role of EGR genes in signal transduction.
  • To understand cellular responses to diverse extracellular signals.

Main Methods:

  • Literature review of transcriptional events in signal transduction.
  • Focus on immediate-early genes and their encoded transcription factors.
  • Analysis of the early growth response group of zinc finger factors.

Main Results:

  • Early growth response genes are induced by mitogens without de novo protein synthesis.
  • These genes encode transcription factors, specifically zinc finger types.
  • EGR genes are activated by various agents, not solely for cell growth.

Conclusions:

  • Early growth response zinc finger transcription factors are key mediators of cellular responses.
  • Characterizing EGR factors provides insights into signal transduction beyond cell growth.
  • These factors are crucial for understanding how cells interpret diverse extracellular signals.

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