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Updated: Jun 4, 2026

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
Published on: April 6, 2022
Tracheobronchial bio-engineering: biotechnology fulfilling unmet medical needs
1Robert-Bosch-Hospital GmbH, Schillerhoehe Hospital, Department of General Thoracic Surgery, Gerlingen, Germany. thorsten.walles@klinik-schillerhoehe.de
Abstract:
The development of substitutes for the human trachea or its bronchial tree represents a niche application in the rapidly advancing scientific field of Regenerative Medicine. Despite a comparatively small research foundation in the field of tracheo-bronchial bioengineering, four different approaches have already been translated into clinical settings and applied in patients. This can be attributed to the lack of established treatment options for a small group of patients with extensive major airway disease. In this review, the clinical background and tissue-specific basics of tracheo-bronchial bioengineering will be evaluated. Focusing on the clinical applications of bioengineered tracheal tissues, a "top-down" or "bedside-to-bench" analysis is performed in order to guide future basic and clinical research activities for airway bioengineering.
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