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Updated: Jun 4, 2026
08:01
A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
Published on: August 29, 2020
An epigenetic Tet a Tet with pluripotency
1FR 8.3 Biosciences, Laboratory of EpiGenetics, Saarland University, Saarbrücken, Germany. j.walter@mx.uni-saarland.de
Cell Stem Cell
|February 8, 2011
Summary
Tet1 and Tet2 enzymes are crucial for establishing the epigenomic landscape in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). These enzymes influence pluripotency gene networks and control cell differentiation potential.
Area of Science:
- Epigenetics
- Stem Cell Biology
- Genetics
Background:
- Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) possess a unique epigenomic landscape.
- This landscape is regulated by DNA and chromatin-modifying enzymes.
- The epigenomic landscape is interconnected with pluripotency gene networks, affecting differentiation.
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