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Stents for proximal esophageal cancer: a case-control study

Robert K Parker¹, Russell E White, Mark Topazian

¹Tenwek Hospital, Bomet, Kenya. rparker3@lifespan.org

Gastrointestinal Endoscopy

|February 8, 2011

Abstract

Background:

Self-expandable metal stents (SEMSs) are an established palliative therapy for esophageal cancer. SEMS placement for cancers near the upper esophageal sphincter (UES) is controversial because of a perceived increased risk of complications.

Objective:

To compare outcomes after patients stented for proximal esophageal cancer (PC) and distal esophageal cancer (DC).

Design:

Matched case-control study from a prospective database.

Setting:

Tertiary referral center, Tenwek Hospital, Bomet, Kenya.

Patients:

All patients with PC located within 6 cm of the UES were matched with randomly selected controls with DC.

Interventions:

Outcomes of PC cases were compared with those of DC controls.

Main Outcome Measurements:

Dysphagia score, complications, median survival.

Results:

A total of 151 patients with PC were identified and were randomly matched with DC controls. Ninety-three case-control pairs had adequate follow-up information available. Mean dysphagia scores (scale 0-4) improved from 3.4 and 3.3 before stenting for PC and DC, respectively, to 1.5 after stenting for both groups (P = .93). Early complications occurred in 6.5% of PC cases and 9.7% of DC controls (P = .44). Late complications occurred in 20.4% of PC cases and 15.1% of DC controls (P = .25). Median survival was 210 days for PC cases and 272 days for DC controls (P = .25). Outcomes were similar for the subgroup of PC cases whose cancer extended to within 2 cm of the UES.

Limitation:

An important limitation is the absence of adequate follow-up data for 58 of the 151 case-control pairs.

Conclusions:

SEMSs effectively palliate dysphagia in PC cases, whereas complication and survival rates are not statistically different from those of DC controls.

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