L-type calcium channel auto-regulation of transcription
Jonathan Satin1, Elizabeth A Schroder, Shawn M Crump
1Department of Physiology, MS-508, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536-0298, USA. jsatin1@uky.edu
Abstract:
L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca(2+) flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator.
Related Concept Videos
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Antihypertensive Drugs: Action of Calcium Channel Blockers
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Master Transcription Regulators
Master Transcription Regulators


