3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor
David A Scott1, Les A Dakin, David J Del Valle
1Cancer Research, AstraZeneca R&D Boston, Waltham, MA 02451, USA. david.scott@astrazeneca.com
Bioorganic & Medicinal Chemistry Letters
|February 8, 2011
Abstract:
3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data.
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