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Updated: Jun 4, 2026
10:04
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Harnessing dendritic cells in cancer
Lionel Apetoh1, Clara Locher, François Ghiringhelli
1INSERM, U866, Dijon, France.
Seminars in Immunology
|February 8, 2011
Summary
Dendritic cells (DCs) are crucial for anti-cancer immunity but are suppressed by the tumor microenvironment. New strategies aim to restore DC function for effective cancer immunotherapy.
Area of Science:
- Immunology
- Oncology
- Cancer Therapy
Background:
- Dendritic cells (DCs) initiate tumor-specific immune responses.
- The tumor microenvironment (TME) suppresses DC function and limits DC-based therapies.
- Understanding DC metabolism in cancer reveals new therapeutic targets.
Purpose of the Study:
- To discuss recent strategies for harnessing dendritic cells (DCs) against cancer.
- To explore how DC metabolism and chemoimmunotherapy can be leveraged for anticancer responses.
Main Methods:
- Review of current research on dendritic cell metabolism in cancer.
- Analysis of evidence for chemo- and radiotherapy-induced DC activation.
- Discussion of therapeutic strategies utilizing DCs.
Main Results:
- DC metabolism research is identifying novel targets to restore anti-cancer immunity.
- Conventional therapies can activate DCs, eliminate immunosuppressive cells, and revert immune suppression.
- Chemoimmunotherapy can exploit DC capacity to trigger anticancer responses.
Conclusions:
- Restoring DC function is key to effective cancer immunotherapy.
- Targeting DC metabolism and combining therapies show promise for cancer treatment.
- Harnessing dendritic cells offers a viable strategy against cancer.
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