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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Spinal Nerves: Plexus II01:21

Spinal Nerves: Plexus II

The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...

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Related Experiment Video

Updated: Jun 4, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Synovial sarcoma of nerve.

Bernd W Scheithauer1, Kimberly K Amrami, Andrew L Folpe

  • 1Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA. scheithauer.bernd@mayo.edu

Human Pathology
|February 8, 2011
PubMed
Summary

Mesenchymal tumors of peripheral nerves are rare, with synovial sarcoma being exceptionally uncommon. This study reports 10 new cases, clarifying its distinction from other nerve tumors and noting its variable prognosis.

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Published on: October 10, 2025

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Peripheral nerve tumors are typically neuroectodermal, originating from Schwann or perineurial cells.
  • Mesenchymal tumors affecting peripheral nerves are rare, arising from epineurial connective tissue.
  • Malignant peripheral nerve neoplasms are predominantly primary nerve sheath tumors, with mesenchymal types being less common.

Purpose of the Study:

  • To report and characterize 10 additional cases of molecularly confirmed synovial sarcoma arising within peripheral nerves.
  • To review the literature and perform a meta-analysis on clinicopathologic features and outcomes of nerve synovial sarcoma.
  • To clarify the distinction between synovial sarcoma and malignant glandular schwannoma using molecular genetics.

Main Methods:

  • Molecular confirmation of synovial sarcoma in 10 nerve tumor cases.
  • Review of existing literature on peripheral nerve synovial sarcoma.
  • Meta-analysis of clinicopathologic features and patient outcomes.

Main Results:

  • 10 new cases of peripheral nerve synovial sarcoma were identified, affecting 7 females and 3 males, with 4 occurring in pediatric patients.
  • Most lesions were initially misdiagnosed as benign nerve sheath tumors or indeterminate on imaging.
  • Molecular genetics confirmed the distinct nature of synovial sarcoma from malignant glandular schwannoma.

Conclusions:

  • Synovial sarcoma of nerve is a rare mesenchymal malignancy distinct from primary nerve sheath tumors.
  • These tumors present a diagnostic challenge, often mimicking benign lesions radiologically.
  • The prognosis for nerve synovial sarcoma is variable, similar to its soft tissue counterpart, necessitating further research for treatment guidelines.