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Updated: Jun 4, 2026
07:02
Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
Published on: February 10, 2026
Chronic kidney disease in patients with ischemic stroke
Yuuko Tsukamoto1, Wakoh Takahashi, Shunya Takizawa
1Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan. kawasi29@is.icc.u-tokai
Summary
Renal dysfunction, indicated by reduced estimated glomerular filtration rate (eGFR), is common in patients with ischemic stroke. Chronic kidney disease is a significant risk factor, particularly for cardiogenic and atherosclerotic stroke types.
Area of Science:
- Nephrology
- Neurology
- Cardiology
Background:
- Renal dysfunction is increasingly recognized as a potential contributor to cerebrovascular diseases.
- Understanding the link between kidney function and stroke subtypes is crucial for risk stratification and prevention.
Purpose of the Study:
- To investigate the association between renal dysfunction, measured by estimated glomerular filtration rate (eGFR), and the occurrence of brain infarction (BI) in ischemic stroke patients.
- To explore the relationship between eGFR levels and specific subtypes of ischemic stroke.
Main Methods:
- A case-control study involving 639 ischemic stroke patients and 314 age-matched controls.
- Renal function was assessed using eGFR calculated from serum creatinine and age.
- Patients were categorized into four eGFR stages (I-IV), with stages III-IV representing significant renal dysfunction.
Main Results:
- Patients with ischemic stroke exhibited a significantly higher prevalence of stage III-IV renal dysfunction (38%) compared to controls (22%).
- The odds ratio for stage III-IV renal dysfunction was significantly elevated in the brain infarction group (1.93).
- Stage III-IV renal dysfunction was associated with increased odds for atherothrombotic (1.81) and cardiogenic (2.25) stroke subtypes, but not lacunar type.
Conclusions:
- Ischemic stroke is frequently accompanied by renal dysfunction.
- Chronic kidney disease may serve as an independent risk factor for ischemic stroke, particularly for cardiogenic and atherosclerotic subtypes.
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