Comparison of three regimens in the management of acute gastroenteritis in infants

Related Experiment Video

Updated: Oct 21, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

P McClean1, A B Lynch, J A Dodge

  • 1Department of Child Health, Queen's University of Belfast, Northern Ireland.

Alimentary Pharmacology & Therapeutics
|October 1, 1990
PubMed

Insights

A low-lactose, low-fat infant feed significantly shortened recovery time and improved weight gain in infants with gastroenteritis compared to conventional or hydrolyzed soya feeds.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Nutrition

Background:

  • Gastroenteritis is a common childhood illness.
  • Nutritional management is crucial for recovery.
  • Optimal infant feeding strategies post-rehydration require investigation.

Purpose of the Study:

  • To evaluate the efficacy of different infant feeds post-rehydration in gastroenteritis.
  • To compare recovery duration and weight changes among feeding groups.

Main Methods:

  • Randomized controlled trial involving 60 infants diagnosed with gastroenteritis.
  • Three feeding groups: low-lactose, low-fat (HN25); conventional formula (SMA); hydrolyzed soya and collagen (Prejomin).
  • Feeds administered in full strength for 5 days post-rehydration.

Main Results:

  • The low-lactose, low-fat group (HN25) had a median loose stool duration of 24 hours, significantly shorter than conventional (119 hours) and hydrolyzed soya (95 hours) groups.
  • The HN25 group showed a mean weight increase of 2.34%, contrasting with a mean loss of 1.45% in the SMA group and a 0.15% increase in the Prejomin group.
  • Statistically significant differences in both stool duration and weight change were observed.

Conclusions:

  • A low-lactose, low-fat infant feed accelerates recovery from gastroenteritis.
  • Early nutritional intervention with specific feeds can positively impact infant weight gain post-illness.
  • HN25 demonstrates superior outcomes in the initial post-rehydration phase of infantile gastroenteritis.

More Related Videos

Probiotic Studies in Neonatal Mice Using Gavage10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Related Concept Videos

Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...