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Related Experiment Video

Updated: Jun 4, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

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Published on: March 15, 2018

TNF-α system and lung function impairment in obesity.

A Lecube¹, G Sampol, X Muñoz

¹Endocrinology Department, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. alecube@vhebron.net

|February 8, 2011

Summary

Soluble TNF-alpha receptor 1 (sTNF-R1) levels correlate with reduced lung function in obese women, indicating potential inflammation

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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

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Published on: April 3, 2017

Area of Science:

Pulmonary Medicine
Immunology
Obesity Research

Background:

Systemic inflammation and abnormal adipose tissue activity may impact pulmonary function.
Soluble TNF-alpha receptors (sTNF-R1, sTNF-R2) are key inflammatory markers.

Purpose of the Study:

To investigate the relationship between circulating sTNF-R1 and sTNF-R2 levels and respiratory function in obese individuals.

Main Methods:

Prospective study of 31 non-diabetic, non-smoking, morbidly obese women.
Pulmonary function tests (spirometry, lung volumes, polygraphy, blood gases) were performed.
ELISA was used to measure sTNF-R1, sTNF-R2, IL-6, and adiponectin levels.

Main Results:

sTNF-R1 positively correlated with BMI and PaCO2, and negatively with FEV1, FEF(25-75), and FVC.
sTNF-R1 independently predicted reduced FEV1 and FVC.
No significant correlation was found between sTNF-R2 and respiratory parameters.

Conclusions:

Elevated sTNF-R1 levels are associated with impaired lung volumes and airflow limitation in morbidly obese patients.
sTNF-R1 may serve as an early indicator of respiratory compromise in obesity.
Further research on anti-TNF-alpha agents for pulmonary function in obesity is warranted.