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[Kawasaki disease in 76 patients. Risk factors for coronary artery aneurysms]

F J Caballero-Mora1, B Alonso-Martín, A Tamariz-Martel-Moreno

  • 1Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España. dr.caballeromora@hotmail.com

Anales De Pediatria (Barcelona, Spain : 2003)
|February 8, 2011
PubMed

Insights

Kawasaki disease, a childhood vasculitis, often presents with fever and rash. Male sex, urticarial rash, and elevated C-reactive protein are key risk factors for developing coronary artery aneurysms in affected children.

Area of Science:

  • Pediatric Rheumatology
  • Pediatric Cardiology
  • Infectious Diseases

Context:

  • Kawasaki disease is a leading cause of acquired heart disease in children.
  • Understanding clinical manifestations and cardiac complications is crucial.
  • Identifying risk factors for cardiac sequelae is essential for early intervention.

Purpose:

  • To describe the clinical and laboratory findings of Kawasaki disease in a specific patient cohort.
  • To determine the incidence of cardiac complications, specifically coronary artery aneurysms.
  • To identify risk factors associated with the development of coronary artery aneurysms.

Summary:

  • A retrospective review of 76 children with Kawasaki disease revealed typical clinical and laboratory findings, including prolonged fever, rash, and elevated inflammatory markers.
  • Coronary artery aneurysms were observed in 15.7% of patients, with mild mitral insufficiency and pericardial effusion in others.
  • Male sex, urticarial rash, and C-reactive protein levels exceeding 10 mg/dL were identified as significant risk factors for coronary artery aneurysms.

Impact:

  • This study highlights the importance of recognizing Kawasaki disease symptoms and risk factors for cardiac complications.
  • Findings contribute to a better understanding of Kawasaki disease epidemiology and risk stratification in pediatric populations.
  • Early identification of at-risk children can potentially lead to timely management and improved cardiovascular outcomes.
Abstract

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