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02:54Evolutionary Relationships through Genome Comparisons
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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02:16Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
03:36Genome Annotation and Assembly
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
01:17Karyotyping
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Mapping Mammalian 3D Genome Interactions with Micro-C-XL
Published on: November 3, 2023
Gobe: an interactive, web-based tool for comparative genomic visualization.
Brent S Pedersen1, Haibao Tang, Michael Freeling
1Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA. bpederse@berkeley.edu
Bioinformatics (Oxford, England)
|February 8, 2011
Summary
Gobe is a web-based tool for exploring comparative genomic data. This interactive application allows simultaneous viewing of multiple genomic regions, enhancing research capabilities.
Area of Science:
- Genomics
- Bioinformatics
Background:
- Gobe is a flash-based web application for comparative genomics.
- It is accessible via a web service or downloadable source code under the MIT license.
Purpose of the Study:
- To provide an interactive tool for viewing and exploring comparative genomic data.
- To support simultaneous visualization of multiple genomic regions.
Main Methods:
- Utilizes a simple text format for data input.
- Employs flash-based rendering for interactive visualization.
- Offers customization options via stylesheets and JavaScript callbacks.
Main Results:
- Enables simultaneous viewing of multiple genomic regions.
- Facilitates exploratory research through an interactive interface.
- Provides accessibility through a web service without installation.
Conclusions:
- Gobe serves as a versatile and accessible tool for comparative genomic data exploration.
- Its design supports efficient visualization and customization for researchers.