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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Related Experiment Video

Updated: Jun 4, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Cell differentiation and matrix organization in engineered teeth.

A Nait Lechguer1, M L Couble, N Labert

  • 1INSERM UMR 977, Faculté de Médecine, 11, rue Humann, F-67085 Strasbourg, France.

Journal of Dental Research
|February 8, 2011
PubMed
Summary
This summary is machine-generated.

Tooth engineering achieved full functional differentiation using embryonic dental cells. Implantation of cell re-associations successfully reproduced mineralized dental tissues and supporting structures.

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Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

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Related Experiment Videos

Last Updated: Jun 4, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells
06:22

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Published on: July 8, 2021

Area of Science:

  • Biomaterials Science
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Tooth engineering requires recapitulating complex cellular and matrix organization.
  • Previous studies demonstrated morphogenesis and histogenesis of dental organs from cultured cells.

Purpose of the Study:

  • To investigate the mineralization and structural organization of dentin, enamel, and cementum.
  • To assess the functional differentiation of dental cells after implantation and tissue formation.

Main Methods:

  • Implantation of cultured embryonic dental cell re-associations.
  • Histology, transmission electron microscopy (TEM), X-ray microanalysis, and electron diffraction.
  • Analysis of mineralized tissue formation and cellular differentiation.

Main Results:

  • Differentiating odontoblasts formed predentin/dentin with polarized cell processes.
  • Functional ameloblasts produced enamel crystals with oriented arrangements.
  • Root development included cementogenesis and periodontal ligament formation with bone interaction.

Conclusions:

  • Implantation of cultured dental cell re-associations enables complete functional differentiation.
  • This approach successfully reproduces dental tissues at cellular, matrix, and mineral levels.
  • This method holds promise for future tooth regeneration strategies.