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Updated: Jun 4, 2026

Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
Published on: May 12, 2023
Chromosome organizaton in simple and complex unicellular organisms
1Institute of Natural Sciences, Massey University, Auckland, New Zealand. j.m.osullivan@massey.ac.nz
Abstract:
The genomes of unicellular organisms form complex 3-dimensional structures. This spatial organization is hypothesized to have a significant role in genomic function. Spatial organization is not limited solely to the three-dimensional folding of the chromosome(s) in genomes but also includes genome positioning, and the folding and compartmentalization of any additional genetic material (e.g. episomes) present within complex genomes. In this comment, I will highlight similarities in the spatial organization of eukaryotic and prokaryotic unicellular genomes.
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