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DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium
Maki Tokumoto1, Tomoaki Ohtsu, Akiko Honda
1Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, Gifu, Japan.
The Journal of Toxicological Sciences
|February 8, 2011
Abstract:
In order to elucidate the transcriptional response of kidney epithelial cells to cadmium, the gene expression pattern was examined in normal rat kidney epithelial cells (NRK-52E cells) exposed to 50 µM cadmium for 4 hr using DNA microarray. Cadmium was found to increase the expression of 73 genes and decrease the expression of 42 genes in NRK-52E cells before the development of cytotoxicity.
