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Updated: Jun 4, 2026
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
Motohiro Shiotani1, Kyoko Nakano, Emiko Yamauchi
1Drug Safety Japan, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Product Creation Systems, Tsukuba, Ibaraki, Japan. m2-shiotani@hhc.eisai.co.jp
Abstract:
Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (sc) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
