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Updated: Jun 4, 2026

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Published on: October 4, 2021
DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium
Yasuyuki Fujiwara1, Akiko Honda, Chika Yamamoto
1Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, Chikusa-ku, Nagoya, Aichi, Japan.
Abstract:
Cadmium (Cd) is a toxic heavy metal that has been shown to induce vascular diseases, such as atherosclerosis. We used DNA microarray to monitor the transcriptional response of human coronary artery endothelial cells (HCAEC) to a non-lethal dose of Cd (10 µM). Out of 35,035 human genes, Cd enhanced the expression of 3 metallothionein (MT)-I subisoform genes, including MT1E, MT1H and MT1B, and reduced the expression of 12 genes, including ISG20 and TK1, 2-fold or greater.
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