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Dyslipidemia and lipid management in HIV-infected patients

Janet Lo1

  • 1Department of Medicine, Harvard Medical School, Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. jlo@partners.org

Current Opinion in Endocrinology, Diabetes, and Obesity
|February 8, 2011
PubMed

Insights

Dyslipidemia is common in people with chronic HIV infection. Rosuvastatin shows promise for managing high cholesterol in this group, but drug interactions must be considered.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Dyslipidemia is prevalent in patients with chronic HIV infection.
  • This condition may increase cardiovascular disease risk in this population.

Purpose of the Study:

  • To review recent data on lipid abnormalities in HIV-infected patients.
  • To summarize current management strategies for dyslipidemia in this cohort.

Main Methods:

  • Literature review of studies published within the last year.
  • Focus on novel lipid-lowering therapies evaluated in HIV patients.

Main Results:

  • Several new lipid-lowering therapies have been assessed in HIV-infected individuals.
  • Rosuvastatin demonstrates good tolerability and efficacy for hypercholesterolemia in this population.

Conclusions:

  • Dyslipidemia remains a significant concern for individuals with HIV.
  • Management requires careful consideration of potential drug-drug interactions between lipid-lowering agents and antiretroviral therapy.
Abstract

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