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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
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Obstructive sleep apnea-specific quality of life and behavioral problems in children with syndromic craniosynostosis

Natalja Bannink1, Marianne Maliepaard, Hein Raat

  • 1Department of Plastic Surgery and Reconstructive Surgery, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands. n.bannink@erasmusmc.nl

Journal of Developmental and Behavioral Pediatrics : JDBP
|February 8, 2011
PubMed

Insights

Children with syndromic craniosynostosis experience lower quality of life due to obstructive sleep apnea (OSA). Behavioral issues are more prevalent in Apert and Muenke syndromes, with OSA severity correlating to these impacts.

Area of Science:

  • Pediatric Health
  • Sleep Medicine
  • Genetics

Background:

  • Syndromic craniosynostosis impacts quality of life and may be associated with behavioral problems.
  • Obstructive sleep apnea (OSA) is a potential complication in these children.

Purpose of the Study:

  • Evaluate the impact of syndromic craniosynostosis on quality of life.
  • Assess the prevalence of behavioral problems in syndromic craniosynostosis.
  • Determine the impact of OSA in syndromic craniosynostosis compared to controls.

Main Methods:

  • Prospective study involving 119 syndromic craniosynostosis patients and 459 controls.
  • Utilized Obstructive Sleep Apnea-18 (OSA-18) and Child Behavior Checklist (CBCL) surveys.
  • Polysomnography was used to diagnose OSA in the craniosynostosis group.

Main Results:

  • Syndromic craniosynostosis patients had higher OSA-18 scores (sleep disturbance, physical suffering, caregiver concerns) than controls.
  • Behavioral problems were observed in 67% of boys with Apert and 50% with Muenke syndrome.
  • OSA severity correlated significantly with OSA-18 and CBCL scores, with moderate OSA linked to higher sleep disturbance and physical suffering.

Conclusions:

  • Obstructive sleep apnea significantly lowers quality of life in children with syndromic craniosynostosis.
  • Behavioral problems are more common in boys with Apert and Muenke syndromes.
  • OSA-18 and CBCL scores reflect OSA severity in this population.
Abstract

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