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WMDA guidelines for subsequent donations following initial BM or PBSCs
D L Confer1, B E Shaw, D H Pamphilon
1National Marrow Donor Program, Minneapolis, MN 55413, USA. dconfer@nmdp.org
Bone Marrow Transplantation
|February 8, 2011
Summary
Subsequent stem cell donations from unrelated donors are increasing. While generally safe, donors should be informed about potential lower yields and counseled before initial donation.
Area of Science:
- Hematology
- Transplantation immunology
Background:
- Increasing activity in unrelated donor hematopoietic stem cell transplantation (SCT).
- Potential need for subsequent stem cell or donor lymphocyte donations in 5-10% of cases.
Purpose of the Study:
- To provide guidance on subsequent donations from unrelated stem cell donors.
- To inform donors about the possibility and implications of repeat donations.
Main Methods:
- Review of current practices and registry guidelines for subsequent donations.
- Analysis of donor safety and stem cell yield in repeat donations.
Main Results:
- Second stem cell donations do not increase donor complication risk.
- Potential for reduced CD34+ cell yield in some repeat donors.
- Subsequent donations are acceptable practice, requiring pre-donation counseling.
Conclusions:
- Registries should counsel potential donors about the possibility of subsequent donations.
- Clear guidelines are needed for medical assessment, request procedures, and donor follow-up for repeat donations.
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